Ocular Surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the corneal

Articulo publicado en la prestigiosa revista Nature donde se desvelaban algunas de las claves del ojo seco.




Andrés Parra, Rodolfo Madrid, Diego Echevarria, Susana del Olmo, Cruz Morenilla-Palao, M Carmen Acosta, Juana Gallar, Ajay Dhaka, Félix Viana & Carlos Belmonte.




Basal tearing is crucial to maintaining ocular surface wetness. Corneal cold thermoreceptors sense small oscillations in ambient temperature and change their discharge accordingly. Deletion of the cold-transducing ion channel Transient receptor potential cation channel subfamily M member 8 (TRPM8) in mice abrogates cold responsiveness and reduces basal tearing without affecting nociceptor-mediated irritative tearing. Warming of the cornea in humans also decreases tearing rate. These findings indicate that TRPM8-dependent impulse activity in corneal cold receptors contributes to regulating basal tear flow.

Nature Medicine 16, 1396-1399 (2010) doi: 10.1038/nm.2264 Andrés Parra, Rodolfo Madrid, Diego Echevarría, Susana del Olmo, Cruz Morenilla-Palao, M. Carmen Acosta, Juana Gallar, Ajay Dhakad, Félix Viana & Calos Belmonte. Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, San Juan de Alicante, Spain. Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile. Fundación de Investigación Oftalmológica, Instituto de Oftalmología Fernández-Vega, Oviedo, Spain. Department of Biological Structure, University of Washington, Seatle, Washington, USA.

request an appointment now

Leave us your details

We will contact you

Call us

Or if you prefer, we can call you:

985 240 141

We are in


Avenida Dres. Fernández-Vega 34 33012, Principality of Asturias (Spain)


C / Príncipe de Vergara  131,  28002 , Madrid (Spain)

Cookies allow us to offer our services. By using our services, you agree to our use of cookies.